Startup Ecosystem
We work with companies across industries, from early stage to in-market, to improve access, equity, and the integration between oral and overall health.

Our startup ecosystem includes our ACCELERATE participants, SMILE Health alumni, and portfolio companies. From teledentistry, pediatric care, diagnostics, AI, and beyond, these companies are meeting critical market and patient needs, connected by our mission to improve overall health through oral health–for all.
Biolectrics | Cleveland, OH
Biolectrics is commercializing OraFlow, a prescription oral care device that uses microcurrent stimulation to treat periodontitis, the sixth most prevalent health condition in the world. OraFlow overcomes barriers of treatment acceptance by providing a painless, cost-effective take-home treatment for patients who would otherwise avoid care.
SMILE
Dentistry.One | Metuchen, NJ
Dentistry.One, a wholly-owned subsidiary of MouthWatch, launched in 2023 as a virtual-first care network that addresses the expectations of today’s modern healthcare consumers with on-demand dental consultations, AI wellness scans, personalized care coordination, and oral health coaching for prioritizing oral and systemic health.
Portfolio
DentKits | Las Vegas, NV
DentKits provides at-home dentures utilizing digital denture and teledental technologies. DentKits is improving access to dental care for underserved and vulnerable populations by offering dentist-prescribed dentures that are both convenient and affordable.
SMILE
DifferentKind | Buena Vista, CO
DifferentKind is an experience-management leader in oral health, producing data and insights from patients and teams that drive improved outcomes for patients, practices, and payers.
SMILE | ACCELERATE
Enable Dental | Austin, TX
Enable Dental offers portable general dentistry and value-added services to seniors, adults with special needs ('I/DD'), and their supporting healthcare organizations across various facilities, homes, PACE centers, and communities.
Portfolio
Feno | Culver, City, CA
Feno is a connected oral health platform that combines smart brushing technology with personalized insights, empowering people to understand, track, and improve their oral health as part of their overall wellness journey.
SMILE
Firstgrin | New York, NY
Firstgrin provides pediatric oral care kits and targeted, evidence-based education via a companion app for families to help prevent oral disease starting in pregnancy and infancy and establish healthy, lifelong oral hygiene habits.
SMILE | ACCELERATE
Grin | New York, NY
Grin is reinventing oral care for everyone. With Grin’s imaging and remote diagnostic solution, patients are connected to doctors remotely, bringing patient convenience, reduction in overhead, and access to responsible care. Grin strives to empower consumers to take control of their own oral health by seeing for the first time what is happening within their mouths and connecting them to accessible resources and diagnostics encouraging preventive care.
SMILE | ACCELERATE | Portfolio
Incisive Technologies | Melbourne, Australia
Incisive’s mission is to advance oral health care and accelerate solutions to the global challenge of tooth decay. Incisive’s BlueCheck is a highly sensitive, easy-to-use, objective measure of early-stage caries to support minimally invasive care. Intellectual property protection extends across all the major global jurisdictions, and they expect BlueCheck to disrupt the current standard of care.
SMILE | Portfolio
Kare Mobile | Louisville, KY
Kare Mobile helps dentists solve for increased productivity and enhanced patient experience. Operating as a mobile dental services organization, Kare Mobile helps close the access gap to oral health care through their proprietary single operator vans that they manufacture. They also provide proprietary software to automate the scheduling process for both mobile and stationary scheduling.
SMILE
KiDDY CAPS | Wilsdorf, Germany
KiDDY CAPS is transforming pediatric dentistry via affordable, minimally invasive zirconia crowns for children, making high-quality caries treatment accessible for every child.
SMILE
Lura | Boston, MA
Wearable blood/interstitial fluid-based monitors disrupted blood-based monitoring from ex vivo (outside the body) lab tests to continual in-body measurements. The same will be true with saliva. Lura Health is leading the way with a first-in-class salivary diagnostic in-mouth wearable for continual health and disease measurements.
SMILE | ACCELERATE
MouthWatch | Metuchen, NJ
MouthWatch is a leader in developing digital technology solutions that drive success for dental professionals, improve oral health care, and enhance the overall patient experience.
Portfolio
OraLiva | Durham, NC
OraLiva provides non-invasive, clinically validated, AI-assisted diagnostics for screening oral lesions. This innovative solution delivers highly accurate diagnostic information to dental and medical providers.
SMILE | ACCELERATE
OraQ | Calgary, Canada
OraQ is a state-of-the-art software solution that harnesses the analytical power of AI and machine learning. It provides advanced patient assessments and detailed risk-profiling in a fraction of the time. Who does it learn from? The thousands of dental professionals who employ OraQ as their assessment tool.
SMILE
OrisDX | Chicago, IL
OrisDX provides patients better clarity on their health through novel saliva-based diagnostics to identify precancer and cancer. Based on innovative research from the University of Chicago, their first product detects oral cavity cancer through noninvasive genetic testing of patients’ saliva.
SMILE | ACCELERATE | Portfolio
SleepArchitects | Newport Beach, CA
SleepArchitects is democratizing access to obstructive sleep apnea diagnosis and treatment for dental professionals and consumers using a simple, convenient, turnkey digital experience. They work closely with dental practitioners in providing the best sleep oral appliance therapy, uniquely customized to treat sleep breathing disorders.
SMILE
Social Cascade | Raleigh, NC
Social Cascade enables providers to engage with patients between office visits with timely and relevant information designed to meet patients where they are, promote equitable access through education, and drive community health outcomes.
SMILE
ThriveLink | St. Louis, MO
ThriveLink deploys AI telephonic enrollment agents to help families verbally enroll in social and health programs including health insurance, food stamps, utility assistance, and more. The solution does not require the internet, a smartphone, or the ability to read.
SMILE
Times Health | Knoxville, TN
Times Health is an AI-powered virtual health assistant that delivers 24/7 dental guidance, symptom support, and preventive care education, empowering people to take control of their oral health, anytime, anywhere.
SMILE
Toothapps | Wayzata, MN
Toothapps advances health data access, interoperability, and real-time patient engagement across the medical and dental care continuum. Its keystone solution, Cair, helps patients access, understand, and act on their complete health history.
SMILE
Umayana | Istanbul, Turkey
Umayana is a biotech company with a range of products, Murnia, which prevent and treat severe cancer and acute wounds with its patented molecular compound and formulations. Umayana helps cancer patients suffering from wounds like oral mucositis.
SMILE | ACCELERATE
Wesper | New York, NY
Wesper is a physician-guided sleep management platform that offers patients personalized treatment plans, all from the comfort of their own homes.
Portfolio
Wide Awake VR | Ann Arbor, MI
WAVR is a better and safer way for people to experience medical procedures without the need for sedatives. When patients use virtual reality to mitigate anxiety, providers can use immersive media content instead of narcotics in the comfort and safety of their offices.
SMILE
Willo | New York, NY
Willo provides automatic toothbrushes designed for children and anyone who struggles with brushing — whether they need extra support or simply a more effective, hassle-free way to maintain daily oral hygiene.
SMILE
Yumlish | Dallas, TX
Yumlish provides tech-enabled, culturally affirming health education programs for Medicaid enrollees, starting in Spanish-speaking populations. Through YumVivo!, Yumlish will provide access to reliable oral health education in these communities.
SMILE
